P21 5 mg – Peptide Hubs
P21 is a synthetic nootropic peptide originally developed to enhance memory, learning, and neurogenesis in preclinical models of brain injury and cognitive decline. It is based on a modified segment of the CNTF (ciliary neurotrophic factor) and penetratin peptide to facilitate blood-brain barrier transport and receptor binding. Peptide Hubs offers P21 in 5 mg high-purity lyophilized form for research use only.
Mechanism of Action
P21 appears to promote neurogenesis, neurotrophic signaling, and synaptic plasticity by enhancing expression of proteins like GAP-43 and BDNF. It also shows potential to regenerate neuronal architecture in animal models of cognitive injury, particularly in aging or chemically-induced brain damage. This review on peptide nootropics discusses emerging candidates like P21 in neurodegeneration and trauma.
Research Applications
- Memory enhancement and cognitive performance studies
- Brain injury and regeneration models
- Alzheimer's and neurodegenerative disorder protocols
- Long-term potentiation and synaptogenesis investigations
P21 is often paired with N-Acetyl Semax Amidate or N-Acetyl Selank Amidate in emotional memory and neuroplasticity studies. For mitochondrial synergy, researchers combine it with Humanin or MOTS-c. DNA repair models frequently include FOX04-DRI in stacked protocols for cellular senescence and neuroprotection.
Technical Details
Compound Type
CNTF-Derived Peptidergic Compound
Structural Sequence
Ac-DGGLAG-NHβ
CNTF-Derived Region
Asp-Gly-Gly-Leu (DGGL)
Structural Modification
C-Terminal Adamantylated Glycine
Molecular Formula
CββHββNβOβ
Molecular Weight
578.7 g/mol
Parent Protein
Ciliary Neurotrophic Factor (CNTF)
Research Status
Experimental / Preclinical
Dosage & Usage Guidelines
- Dosage: 250–500 mcg per day (subcutaneous or intranasal)
- Cycle: Typically 10–30 days in learning or neuroregeneration protocols
- Storage: Store lyophilized peptide at -20°C and reconstituted solution at 2–8°C
Stacking Recommendations
- N-Acetyl Semax Amidate – for BDNF synergy
- Humanin – neuroprotective synergy
- FOX04-DRI – for senolytic brain aging models
- MOTS-c – mitochondrial coactivation
Safety & Legal Status
P21 is not FDA-approved and is sold strictly for laboratory research. It has shown low toxicity and no hormonal disruption in rodent studies. No known aromatization, liver stress, or cardiovascular effects have been reported. Use in accordance with institutional and regulatory research protocols.
Shipping & Product Authenticity
USA Domestic
4–5 business days
International
13–15 business days
Order Processing
24–48 business hours
Tracking
Tracking number provided
Direct Supply & Discreet Delivery
This product is supplied through the official Peptide Hubs distribution chain and shipped in original manufacturer packaging. The outer shipping package remains discreet, with privacy-focused handling and no unnecessary external product details.
What to Expect
- β Orders are processed after payment confirmation
- β USA Domestic shipping is typically faster when local stock is selected
- β International orders include tracking, though update frequency may vary by destination
- β Multiple warehouses may result in separate shipments when applicable
Authenticity support: official Peptide Hubs presentation, batch-linked lab proof, and original packaging help reinforce product legitimacy and buyer confidence.
Verified Supply
For complete delivery details, tracking policy, and reshipment terms, please see our Shipping Info page.
Storage
Store the lyophilized powder at controlled room temperature (15–25°C) in a dry, dark place, away from direct light and moisture. The unopened vial should be kept in its original packaging to maintain stability.
After reconstitution, store the solution at 2–8°C and use within 14 days. Do not freeze. Discard any unused portion after the recommended storage period. Before use, inspect the solution and avoid use if it appears cloudy, discolored, or contains particulate matter, or if the vial or seal is compromised.
Keep out of reach of children. Follow proper handling and sterile injection practices during research use.
Proper storage conditions help maintain product stability and consistent performance across the product's shelf life.
Frequently Asked Questions
What is P21 peptide used for?
P21 is used in research focused on memory improvement, brain regeneration, neurodegeneration, and cognitive enhancement models.
Is P21 safe in lab studies?
In animal models, P21 shows a strong safety profile with no hepatotoxicity, blood pressure changes, or hormonal effects.
What peptides stack well with P21?
P21 is commonly stacked with Semax, Selank, Humanin, and FOX04-DRI to explore synergistic effects on cognition and brain aging.
Is P21 approved for human use?
No. P21 is not approved by the FDA or any regulatory body for human or veterinary use. It is intended for laboratory research only.
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