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MOTS-c 5 mg
Peptide Hubs

MOTS-c 5 mg

Product Details Peptide Hubs
Active Substance MOTS-c Mitochondrial-derived peptide
Strength 5 mg per vial
Package 1 × 2 mL vial 10 mg labeled content
Form Lyophilized powder
Research Class Mitochondrial peptide
Peptide Type 16-amino-acid peptide Mitochondrial 12S rRNA encoded
Human Half-Life Not established
Research Focus Metabolic signaling AMPK-associated pathways
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MOTS-c 5 mg – Peptide Hubs

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondria-derived peptide (MDP) encoded within the mitochondrial genome. It plays a key role in cellular energy regulation, insulin sensitivity, and metabolic adaptation. Peptide Hubs offers MOTS-c in a high-purity 5 mg lyophilized vial, suitable for metabolic, aging, and performance-related research applications.

Mechanism of Action

MOTS-c modulates gene expression by translocating to the nucleus under metabolic stress. It activates AMPK and SIRT pathways, promoting fat oxidation, glucose utilization, and mitochondrial biogenesis. Its signaling is crucial for maintaining insulin sensitivity and cellular resilience. For more background, refer to this NIH article on MOTS-c in metabolic regulation.

Primary Research Applications

  • Metabolic flexibility and mitochondrial health studies
  • Insulin resistance and glucose uptake models
  • Fat loss and energy expenditure protocols
  • Longevity and oxidative stress response research

In mitochondrial optimization stacks, MOTS-c may be combined with Humanin to study synergistic stress response and cellular repair. It is also often paired with Semaglutide in metabolic modulation studies or with FOX04-DRI for senolytic and anti-aging synergy. Researchers may also include L-Glutathione to monitor oxidative defense during high-energy turnover models.

Technical Details

Peptide Type
Mitochondrial-Derived Peptide
Peptide Sequence
MRWQEMGYIFYPRKLR
Peptide Length
16 Amino-Acid Residues
Terminal Form
H-MRWQEMGYIFYPRKLR-OH
Molecular Formula
C₁₀₁H₁₅₂N₂₈O₂₂S₂
Molecular Weight
2174.6 g/mol
CAS Number
1627580-64-6
PubChem CID
146675088
Genetic Origin
Mitochondrial 12S rRNA Region
Research Pathway
AMPK-Associated Metabolic Signaling

Dosage & Usage Guidelines

  • Dosage: 5–15 mg per week (divided into 2–3 injections)
  • Administration: Subcutaneous injection
  • Cycle Duration: 4–12 weeks depending on research scope

Stacking Suggestions

  • Humanin – synergistic MDP for longevity and metabolic stress adaptation
  • Semaglutide – for enhanced glycemic control and weight-loss synergy
  • FOX04-DRI – for age-related mitochondrial and senescence studies
  • L-Glutathione – to assess antioxidant status under metabolic load

Safety & Legal Status

MOTS-c is not approved by the FDA and is intended strictly for research use only. No hepatotoxic, androgenic, or aromatizing effects have been reported in preclinical data. It has shown excellent tolerability in animal and in vitro studies. For related clinical investigations, refer to ClinicalTrials.gov.

Shipping & Product Authenticity

USA Domestic
4–5 business days
International
13–15 business days
Order Processing
24–48 business hours
Tracking
Tracking number provided
Direct Supply & Discreet Delivery

This product is supplied through the official Peptide Hubs distribution chain and shipped in original manufacturer packaging. The outer shipping package remains discreet, with privacy-focused handling and no unnecessary external product details.

What to Expect

  • ✔ Orders are processed after payment confirmation
  • ✔ USA Domestic shipping is typically faster when local stock is selected
  • ✔ International orders include tracking, though update frequency may vary by destination
  • ✔ Multiple warehouses may result in separate shipments when applicable
Authenticity support: official Peptide Hubs presentation, batch-linked lab proof, and original packaging help reinforce product legitimacy and buyer confidence.
Verified Supply

For complete delivery details, tracking policy, and reshipment terms, please see our Shipping Info page.

Storage

Store the lyophilized powder at controlled room temperature (15–25°C) in a dry, dark place, away from direct light and moisture. The unopened vial should be kept in its original packaging to maintain stability.

After reconstitution, store the solution at 2–8°C and use within 14 days. Do not freeze. Discard any unused portion after the recommended storage period. Before use, inspect the solution and avoid use if it appears cloudy, discolored, or contains particulate matter, or if the vial or seal is compromised.

Keep out of reach of children. Follow proper handling and sterile injection practices during research use.

Proper storage conditions help maintain product stability and consistent performance across the product's shelf life.

Frequently Asked Questions

What is MOTS-c used for in research?

MOTS-c is researched for its effects on metabolic regulation, mitochondrial function, insulin sensitivity, and exercise performance models.

Is MOTS-c a hormone?

No. MOTS-c is a mitochondria-derived peptide, not a hormone. It acts through gene regulation and AMPK activation without binding classical receptors.

Does MOTS-c aid in fat loss research?

Yes. MOTS-c enhances fat oxidation and improves metabolic efficiency, making it a focus in fat loss and obesity-related research protocols.

Is MOTS-c FDA approved?

No. MOTS-c is not FDA-approved and is sold strictly for laboratory research use in preclinical settings.

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