AICAR 50 MG

AICAR 50 mg – Peptide Hubs

AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is a powerful research compound that has drawn attention in athletic and scientific communities for its ability to enhance mitochondrial activity, endurance capacity, and fat metabolism. The 50 mg lyophilized peptide offered by Peptide Hubs is formulated for purity and precision in experimental settings.

What Is AICAR?

AICAR functions as an AMPK activator, mimicking the effects of exercise at the cellular level. Originally developed for metabolic and ischemic studies, it has been investigated for its effects on energy homeostasis, endurance performance, and glucose uptake. In rodents and primates, AICAR has demonstrated the potential to increase stamina without physical training.

Mechanism of Action

AICAR activates AMP-activated protein kinase (AMPK), a key enzyme that signals the body to enhance energy production, increase fatty acid oxidation, and improve glucose transport. This process leads to improved endurance, enhanced insulin sensitivity, and potentially accelerated fat loss. Learn more about the biochemical pathway in this NIH-reviewed article on AMPK activation.

Applications in Research & Bodybuilding

While AICAR is not approved for human consumption, it's widely researched in sports performance, fat loss, and metabolic studies. In experimental bodybuilding contexts, it is often used to simulate the effects of cardio during cutting cycles. Users typically pair AICAR with compounds like GW501516 (Cardarine) to maximize endurance and lipolysis.

Suggested Experimental Use

• Research Dosage: 25–50 mg daily, subcutaneously or intraperitoneally
• Cycle Length: 10–20 days in most test environments
• Best Used: Prior to endurance challenges or high-fat diet research

Stacking Options

AICAR is often combined with other metabolic or fat-burning peptides. Popular stacks include:

• AOD 9604 – for additional lipolytic effects
• Clenbuterol 40 mcg – to boost thermogenesis
• Semaglutide 5 mg – for appetite suppression and glucose balance

This synergistic combination enhances mitochondrial output, fat burning, and appetite regulation during a cutting cycle.

Side Effects & Considerations

AICAR is generally well-tolerated in laboratory settings. Some studies have reported temporary fatigue, hypoglycemia, or mild nausea. It is non-hepatotoxic, does not cause water retention or aromatize, making it suitable for research tied to lean composition and cardiovascular efficiency. All applications must remain within approved research scope.

Legal Status & Compliance

AICAR is not FDA-approved and is sold strictly for laboratory research purposes. It remains on WADA's list of prohibited substances for athletic use. Learn more about current regulations on AICAR by visiting the WADA Prohibited List.

Frequently Asked Questions