AICAR 50 mg – Peptide Hubs
AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is a powerful research compound that has drawn attention in athletic and scientific communities for its ability to enhance mitochondrial activity, endurance capacity, and fat metabolism. The 50 mg lyophilized peptide offered by Peptide Hubs is formulated for purity and precision in experimental settings.
What Is AICAR?
AICAR functions as an AMPK activator, mimicking the effects of exercise at the cellular level. Originally developed for metabolic and ischemic studies, it has been investigated for its effects on energy homeostasis, endurance performance, and glucose uptake. In rodents and primates, AICAR has demonstrated the potential to increase stamina without physical training.
Mechanism of Action
AICAR activates AMP-activated protein kinase (AMPK), a key enzyme that signals the body to enhance energy production, increase fatty acid oxidation, and improve glucose transport. This process leads to improved endurance, enhanced insulin sensitivity, and potentially accelerated fat loss. Learn more about the biochemical pathway in this NIH-reviewed article on AMPK activation.
Applications in Research & Bodybuilding
While AICAR is not approved for human consumption, it's widely researched in sports performance, fat loss, and metabolic studies. In experimental bodybuilding contexts, it is often used to simulate the effects of cardio during cutting cycles. Users typically pair AICAR with compounds like GW501516 (Cardarine) to maximize endurance and lipolysis.
Technical Details
Compound Type
Nucleoside Analogue
Molecular Formula
CβHββNβOβ
Molecular Weight
258.23 g/mol
Active Metabolite
ZMP (AICAR Monophosphate)
Pathway Association
AMPK Signaling
Development Status
Experimental / Investigational
Dosage & Usage Guidelines
- Research Dosage: 25–50 mg daily, subcutaneously or intraperitoneally
- Cycle Length: 10–20 days in most test environments
- Best Used: Prior to endurance challenges or high-fat diet research
Stacking Options
AICAR is often combined with other metabolic or fat-burning peptides. Popular stacks include:
- AOD 9604 – for additional lipolytic effects
- Clenbuterol 40 mcg – to boost thermogenesis
- Semaglutide 5 mg – for appetite suppression and glucose balance
This synergistic combination enhances mitochondrial output, fat burning, and appetite regulation during a cutting cycle.
Side Effects & Considerations
AICAR is generally well-tolerated in laboratory settings. Some studies have reported temporary fatigue, hypoglycemia, or mild nausea. It is non-hepatotoxic, does not cause water retention or aromatize, making it suitable for research tied to lean composition and cardiovascular efficiency. All applications must remain within approved research scope.
Legal Status & Compliance
AICAR is not FDA-approved and is sold strictly for laboratory research purposes. It remains on WADA's list of prohibited substances for athletic use. Learn more about current regulations on AICAR by visiting the WADA Prohibited List.
Shipping & Product Authenticity
USA Domestic
4–5 business days
International
13–15 business days
Order Processing
24–48 business hours
Tracking
Tracking number provided
Direct Supply & Discreet Delivery
This product is supplied through the official Peptide Hubs distribution chain and shipped in original manufacturer packaging. The outer shipping package remains discreet, with privacy-focused handling and no unnecessary external product details.
What to Expect
- β Orders are processed after payment confirmation
- β USA Domestic shipping is typically faster when local stock is selected
- β International orders include tracking, though update frequency may vary by destination
- β Multiple warehouses may result in separate shipments when applicable
Authenticity support: official Peptide Hubs presentation, batch-linked lab proof, and original packaging help reinforce product legitimacy and buyer confidence.
Verified Supply
For complete delivery details, tracking policy, and reshipment terms, please see our Shipping Info page.
Storage
Store the lyophilized powder at controlled room temperature (15–25°C) in a dry, dark place, away from direct light and moisture. The unopened vial should be kept in its original packaging to maintain stability.
After reconstitution, store the solution at 2–8°C and use within 14 days. Do not freeze. Discard any unused portion after the recommended storage period. Before use, inspect the solution and avoid use if it appears cloudy, discolored, or contains particulate matter, or if the vial or seal is compromised.
Keep out of reach of children. Follow proper handling and sterile injection practices during research use.
Proper storage conditions help maintain product stability and consistent performance across the product's shelf life.
Frequently Asked Questions
What is AICAR used for?
AICAR is a research peptide used to study endurance enhancement, fat metabolism, and AMPK pathway activation. It is not approved for human use and is intended solely for research purposes.
How does AICAR affect fat loss?
AICAR activates AMPK, promoting fatty acid oxidation and glucose uptake. This mimics exercise at the cellular level, which may enhance fat-burning in lab models.
Can AICAR be stacked with other compounds?
Yes, AICAR is often stacked with Cardarine, Clenbuterol, or AOD 9604 in experimental settings to enhance endurance and fat loss outcomes.
Is AICAR legal for purchase in the USA?
Yes, AICAR can be legally purchased in the USA for research use. It is not approved for human consumption and remains banned by WADA for athletes.
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