Peptide Hubs
Latest laboratory result 11.04 mg/vial January 12, 2026 · 138.00% of 8 mg label claim · Batch #GAPE2212 View
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PE-22-28 8 mg
Product Details Peptide Hubs
Active Substance PE-22-28 Spadin-derived peptide
Strength 8 mg/vial
Vial Size 2 mL vial
Form Lyophilized powder For reconstitution
Research Class Neuropeptide Spadin-derived analogue
Peptide Length 7 amino acids GVSWGLR
Human Half-Life Not established
Primary Target TREK-1 K2P potassium channel
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$45.00
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PE-22-28 8 mg – Peptide Hubs
PE-22-28 is a research peptide derived from the loop region of brain-derived neurotrophic factor (BDNF), designed to mimic its effects without the adverse side effects associated with full-length BDNF. It selectively targets TrkB receptors, promoting synaptic plasticity, neurogenesis, and resilience to stress. Peptide Hubs offers PE-22-28 in a 8 mg high-purity lyophilized format suitable for neurological and psychiatric research.
Lab Test Result
Mechanism of Action
PE-22-28 activates TrkB receptors in a manner similar to endogenous BDNF but avoids activation of the p75NTR receptor, which is linked to apoptosis. This selective targeting makes it ideal for studying mood regulation, anxiety, memory consolidation, and neuronal repair without risk of excitotoxicity. In preclinical trials, it demonstrated strong anxiolytic and antidepressant-like effects. A 2017 study confirmed its neurotrophic properties and potential applications in mood and neurodegeneration models.
Key Research Applications
- BDNF pathway activation and TrkB receptor studies
- Stress resilience and mood stabilization models
- Cognitive enhancement and memory retention research
- Neurodegeneration and neuroplasticity protocols
PE-22-28 is often combined with other central-acting peptides like N-Acetyl Semax Amidate or N-Acetyl Selank Amidate in cognitive and mood research. For mitochondrial synergy, Humanin or MOTS-c are commonly stacked. Neurorepair models frequently also use FOX04-DRI.
Suggested Experimental Use
- Dosage: 1–3 mg per day
- Route: Intranasal or subcutaneous
- Cycle: 10–30 days in behavioral and cognitive protocols
Stacking Suggestions
- N-Acetyl Semax Amidate – BDNF synergy
- Humanin – mitochondrial neuroprotection
- FOX04-DRI – senolytic cognitive repair
- MOTS-c – neuro-metabolic resilience
Safety & Legal Status
PE-22-28 is not FDA-approved and is offered exclusively for scientific and research use only. No androgenic, estrogenic, or hepatotoxic effects have been reported in animal studies. Researchers must ensure proper storage and compliance with local research regulations.
Frequently Asked Questions
What is PE-22-28 used for in research?
PE-22-28 is studied for its effects on neuroplasticity, TrkB receptor activation, mood stabilization, and memory enhancement.
Does PE-22-28 mimic BDNF?
Yes. PE-22-28 mimics BDNF's action on the TrkB receptor but avoids the apoptotic signaling of the p75NTR pathway.
What other peptides stack well with PE-22-28?
Common stacks include Semax Amidate, Humanin, FOX04-DRI, and MOTS-c in neuroregeneration and nootropic research models.
Is PE-22-28 FDA approved?
No. PE-22-28 is not FDA-approved and is intended strictly for laboratory and research purposes only.
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