PE-22-28 8 MG

PE-22-28 8 mg – Peptide Hubs

PE-22-28 is a research peptide derived from the loop region of brain-derived neurotrophic factor (BDNF), designed to mimic its effects without the adverse side effects associated with full-length BDNF. It selectively targets TrkB receptors, promoting synaptic plasticity, neurogenesis, and resilience to stress. Peptide Hubs offers PE-22-28 in a 8 mg high-purity lyophilized format suitable for neurological and psychiatric research.

Mechanism of Action

PE-22-28 activates TrkB receptors in a manner similar to endogenous BDNF but avoids activation of the p75NTR receptor, which is linked to apoptosis. This selective targeting makes it ideal for studying mood regulation, anxiety, memory consolidation, and neuronal repair without risk of excitotoxicity. In preclinical trials, it demonstrated strong anxiolytic and antidepressant-like effects. A 2017 study confirmed its neurotrophic properties and potential applications in mood and neurodegeneration models.

Key Research Applications

• BDNF pathway activation and TrkB receptor studies
• Stress resilience and mood stabilization models
• Cognitive enhancement and memory retention research
• Neurodegeneration and neuroplasticity protocols

PE-22-28 is often combined with other central-acting peptides like N-Acetyl Semax Amidate or N-Acetyl Selank Amidate in cognitive and mood research. For mitochondrial synergy, Humanin or MOTS-c are commonly stacked. Neurorepair models frequently also use FOX04-DRI.

Suggested Experimental Use

• Dosage: 1–3 mg per day
• Route: Intranasal or subcutaneous
• Cycle: 10–30 days in behavioral and cognitive protocols

Stacking Suggestions

• N-Acetyl Semax Amidate – BDNF synergy
• Humanin – mitochondrial neuroprotection
• FOX04-DRI – senolytic cognitive repair
• MOTS-c – neuro-metabolic resilience

Safety & Legal Status

PE-22-28 is not FDA-approved and is offered exclusively for scientific and research use only. No androgenic, estrogenic, or hepatotoxic effects have been reported in animal studies. Researchers must ensure proper storage and compliance with local research regulations.

Frequently Asked Questions