Peptide Hubs
Latest laboratory result 11.04 mg per vial January 12, 2026 · 110.40% of label claim · Batch GAPE2212 View
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PE-22-28 10 mg
Product Details Peptide Hubs
Active Substance PE-22-28 Spadin-derived peptide
Strength 10 mg/vial
Vial Size 2 mL vial
Form Lyophilized powder For reconstitution
Research Class Neuropeptide Spadin-derived analogue
Peptide Length 7 amino acids GVSWGLR
Human Half-Life Not established
Primary Target TREK-1 K2P potassium channel
$27.00
$45.00
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PE-22-28 8 mg – Peptide Hubs
PE-22-28 is a research peptide derived from the loop region of brain-derived neurotrophic factor (BDNF), designed to mimic its effects without the adverse side effects associated with full-length BDNF. It selectively targets TrkB receptors, promoting synaptic plasticity, neurogenesis, and resilience to stress. Peptide Hubs offers PE-22-28 in a 8 mg high-purity lyophilized format suitable for neurological and psychiatric research.
Mechanism of Action
PE-22-28 activates TrkB receptors in a manner similar to endogenous BDNF but avoids activation of the p75NTR receptor, which is linked to apoptosis. This selective targeting makes it ideal for studying mood regulation, anxiety, memory consolidation, and neuronal repair without risk of excitotoxicity. In preclinical trials, it demonstrated strong anxiolytic and antidepressant-like effects. A 2017 study confirmed its neurotrophic properties and potential applications in mood and neurodegeneration models.
Key Research Applications
- BDNF pathway activation and TrkB receptor studies
- Stress resilience and mood stabilization models
- Cognitive enhancement and memory retention research
- Neurodegeneration and neuroplasticity protocols
PE-22-28 is often combined with other central-acting peptides like N-Acetyl Semax Amidate or N-Acetyl Selank Amidate in cognitive and mood research. For mitochondrial synergy, Humanin or MOTS-c are commonly stacked. Neurorepair models frequently also use FOX04-DRI.
Technical Details
Peptide Type
Synthetic Linear Heptapeptide
Peptide Sequence
Gly-Val-Ser-Trp-Gly-Leu-Arg (GVSWGLR)
Peptide Length
7 Amino-Acid Residues
Terminal Form
H-GVSWGLR-OH
Peptide Origin
Shortened Spadin Analogue
Molecular Formula
C₃₅H₅₅N₁₁O₉
Molecular Weight
773.89 g/mol
CAS Number
1801959-12-5
PubChem CID
165437303
Research Target
TREK-1 (K2P2.1) Potassium Channel
Dosage & Usage Guidelines
- Dosage: 1–3 mg per day
- Route: Intranasal or subcutaneous
- Cycle: 10–30 days in behavioral and cognitive protocols
Stacking Suggestions
- N-Acetyl Semax Amidate – BDNF synergy
- Humanin – mitochondrial neuroprotection
- FOX04-DRI – senolytic cognitive repair
- MOTS-c – neuro-metabolic resilience
Safety & Legal Status
PE-22-28 is not FDA-approved and is offered exclusively for scientific and research use only. No androgenic, estrogenic, or hepatotoxic effects have been reported in animal studies. Researchers must ensure proper storage and compliance with local research regulations.
Batch-Tested & Verified Lab Results
Shipping & Product Authenticity
USA Domestic
4–5 business days
International
13–15 business days
Order Processing
24–48 business hours
Tracking
Tracking number provided
Direct Supply & Discreet Delivery
This product is supplied through the official Peptide Hubs distribution chain and shipped in original manufacturer packaging. The outer shipping package remains discreet, with privacy-focused handling and no unnecessary external product details.
What to Expect
- ✔ Orders are processed after payment confirmation
- ✔ USA Domestic shipping is typically faster when local stock is selected
- ✔ International orders include tracking, though update frequency may vary by destination
- ✔ Multiple warehouses may result in separate shipments when applicable
Authenticity support: official Peptide Hubs presentation, batch-linked lab proof, and original packaging help reinforce product legitimacy and buyer confidence.
Verified Supply
For complete delivery details, tracking policy, and reshipment terms, please see our Shipping Info page.
Storage
Store the lyophilized powder at controlled room temperature (15–25°C) in a dry, dark place, away from direct light and moisture. The unopened vial should be kept in its original packaging to maintain stability.
After reconstitution, store the solution at 2–8°C and use within 14 days. Do not freeze. Discard any unused portion after the recommended storage period. Before use, inspect the solution and avoid use if it appears cloudy, discolored, or contains particulate matter, or if the vial or seal is compromised.
Keep out of reach of children. Follow proper handling and sterile injection practices during research use.
Proper storage conditions help maintain product stability and consistent performance across the product's shelf life.
Frequently Asked Questions
What is PE-22-28 used for in research?
PE-22-28 is studied for its effects on neuroplasticity, TrkB receptor activation, mood stabilization, and memory enhancement.
Does PE-22-28 mimic BDNF?
Yes. PE-22-28 mimics BDNF's action on the TrkB receptor but avoids the apoptotic signaling of the p75NTR pathway.
What other peptides stack well with PE-22-28?
Common stacks include Semax Amidate, Humanin, FOX04-DRI, and MOTS-c in neuroregeneration and nootropic research models.
Is PE-22-28 FDA approved?
No. PE-22-28 is not FDA-approved and is intended strictly for laboratory and research purposes only.
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